通过可注射和自动供电的视网膜纳米天线进行哺乳动物近红外图像视觉
Yuqian Ma1, Jin Bao2, Yuanwei Zhang3
1Hefei National Laboratory for Physical Sciences at the Microscale, Neurodegenerative Disorder Research Center, CAS Key Laboratory of Brain Function and Disease, School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China.
Cell
|March 5, 2019
概括
科学家们开发了可注射的纳米粒子,使老鼠能够看到近红外 (NIR) 光,这是哺乳动物看不见的光谱. 这一突破使得人们可以在白天看到平行视觉,
科学领域:
- 眼科 眼科
- 纳米技术
- 神经科学
背景情况:
- 哺乳动物仅能看到可见光 (700nm以下) 由于素的特性.
- 探测无形近红外 (NIR) 光是一种重要的技术和生物挑战.
- 现有的NIR检测方法缺乏生物整合,并且往往具有侵入性.
研究的目的:
- 开发一种使哺乳动物能够感知NIR光的方法.
- 创建一个生物集成的NIR视觉系统,
- 探索升级纳米粒子的视觉增强潜力.
主要方法:
- 开发可注射的光受体结合上转化纳米粒子 (pbUCNP).
- 将pbUCNP固定在视网膜的光受体上,作为NIR光传感器.
- 使用单光受体记录,电视网膜图,皮质记录和小鼠视觉行为测试.
主要成果:
- 接受pbUCNP注射的小鼠表现出感知NIR光的能力.
- 被治疗的小鼠可以区分NIR光模式和复杂的NIR形状.
- 与环境白天光线兼容,并与本地视觉并行.
结论:
- 可以注射的pbUCNP成功地在哺乳动物中产生功能性的NIR光图像视力.
- 这项技术为视觉增强和生物集成纳米设备提供了一种新的方法.
- 这种方法提供了一种安全有效的方法来克服自然的视觉限制.
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