在排卵期妇女中,冷细胞转移与新鲜细胞转移:多中心随机对照试验
Daimin Wei1, Jia-Yin Liu2, Yun Sun3
1Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China; The Key Laboratory of Reproductive Endocrinology of Ministry of Education, Jinan, China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Jinan, China.
Lancet (London, England)
|March 5, 2019
概括
与新鲜转移相比,冷单胞胎转移显著增加了单胞胎活产率. 需要进一步的研究,以了解相关的子宫前风险增加.
科学领域:
- 生殖医学
- 治疗不孕症
- 胚胎学
背景情况:
- 建议选择性单个胚胎移植 (eSET),但对较低的怀孕率表示担忧.
- 扩展胚胎培养和选择性冷保存胚胎以延迟转移可能会提高eSET结果.
研究的目的:
- 为了比较选择性冷单卵母细胞转移和新鲜单卵母细胞转移之间的单个活产率.
主要方法:
- 一个多中心,非盲目的,随机对照试验,涉及1650名女性进行第一次体外受精周期.
- 参与者被随机分配为新鲜或冷的单个胚胎细胞移植.
- 主要结局是单个活产率,根据治疗意向进行分析.
主要成果:
- 与新鲜单胞胎移植 (40%) 相比,冷单胞胎移植的活产率更高.
- 在卵巢过度刺激综合征,流产,产科并发症或新生儿发病率方面没有发现显著差异.
- 在冷单个胚胎细胞移植组中发现了更高的妊娠前风险 (3. 1% 与 1. 0% 相比).
结论:
- 选择性冷单个胚胎细胞转移改善了正常周期和良好的预后进行体外受精的妇女的单个活产率.
- 在冷胚胎转移后出现子宫前的高风险需要进一步调查.
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