带正电荷的顺序定义的功能性聚合物的可扩展合成
Bo Zhao1, Zhengguo Gao1,2, Yaochen Zheng2
1MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering , Zhejiang University , Hangzhou 310027 , P. R. China.
Journal of the American Chemical Society
|March 6, 2019
概括
研究人员开发了一种可扩展的方法, 这一突破为信息传输和生物相关领域的先进应用提供了高产量和可编程性.
科学领域:
- 聚合物化学
- 有机合成
- 材料科学
背景情况:
- 合成配序定义的聚合物与阴离子骨架存在重大挑战.
- 精确控制聚合物结构对于先进的材料性能和应用至关重要.
研究的目的:
- 开发一种可扩展和高效的合成序列定义的聚合物方法.
- 描述这些新型聚合物的精确结构和特性.
- 探索它们在信息传输和生物应用方面的潜力.
主要方法:
- 交替的Menschutkin反应和铜催化的酸循环添加.
- 在没有保护组或固体支的情况下使用反极策略 (PIS).
- 使用马尔迪-托夫质谱法进行序列解码.
主要成果:
- 成功合成了可扩展的序定义高达12个重复单元和四级骨的聚合物.
- 通过PIS方法获得高收益率 (超过12个阶段高达68%,每阶段高达95%).
- 证明了高可编程的聚合物结构 (骨干,序列,侧组,终端,拓) 和简单的序列信息解码.
- 由此产生的聚合物具有水溶性,正电荷,适合生物应用.
结论:
- 开发的方法提供了一个具有成本效益和可扩展的途径,用于精确合成定序聚合物.
- 这些聚合物具有出色的可编程性和简单的序列解码,使信息存储和检索具有新的可能性.
- 这些水溶性聚合物可用于各种生物应用,包括DNA凝结,基因转移和药物输送.
相关概念视频
Polymers: Defining Molecular Weight
3.8K
Unlike small molecules with definite molecular weights, polymers are a mixture of individual polymer chains of varying lengths, each with a unique molecular weight. So, the molecular weight of a polymer is expressed as an average value based on the average size of the polymer chains. The two most common forms of averages used for polymers are the number average molecular weight and weight average molecular weight.
The number average molecular weight (Mn) is the summation of the number...
The number average molecular weight (Mn) is the summation of the number...
3.8K
Ions and Ionic Charges
78.9K
In ordinary chemical reactions, the nucleus — which contains the protons and neutrons of each atom and thus identifies the element — remains unchanged. Electrons, however, can be added to atoms by transfer from other atoms, lost by transfer to other atoms, or shared with other atoms. The transfer and sharing of electrons among atoms govern the chemistry of the elements. During the formation of some compounds, atoms gain or lose electrons to form electrically charged particles called...
78.9K
Polymers
40.7K
The word polymer is derived from the Greek words “poly” which means “many” and “mer” which means “parts”. Polymers are long chains of molecules composed of repeating units of smaller molecules, known as monomers. They either occur naturally, such as DNA and proteins, or can be constructed synthetically, like plastics. They have varied structural characteristics, such as linear chains, branched chains, or complex networks, that contribute to the...
40.7K
Formal Charges
40.3K
In some cases, there are seemingly more than one valid Lewis structures for molecules and polyatomic ions. The concept of formal charges can be used to help predict the most appropriate Lewis structure when more than one reasonable structure exists.
40.3K
Synthesis and Functions of Calcitonin
4.6K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
4.6K
Dehydration Synthesis
149.4K
Overview
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...
149.4K


