单个神经元的干扰显示了V1中的特征性竞争
Selmaan N Chettih1, Christopher D Harvey2
1Department of Neurobiology, Harvard Medical School, Boston, MA, USA.
Nature
|March 8, 2019
概括
影响映射直接测量神经元如何改变感官表现. 在视觉皮层中, 这揭示了"像-抑制-像"机制,
科学领域:
- 神经科学
- 计算神经科学
- 系统神经科学
背景情况:
- 神经计算通常从连接和活动中间接推断出来.
- 需要直接测量单个神经元如何影响其他神经元以了解人口动态.
研究的目的:
- 引入和验证"影响映射"作为直接测量单个神经元对神经表征的影响的方法.
- 研究主要视觉皮层 (V1) 的2/3层刺激神经元如何影响其邻居的活动.
主要方法:
- 开发了使用双光子光遗传学进行单个神经元向刺激的"影响映射".
- 使用成像记录醒着小鼠邻近神经元的激增活动.
- 在光遗传干扰和成像期间向小鼠呈现视觉刺激.
主要成果:
- 在V1层2/3的刺激神经元表现出中心-周围影响的特征,抑制邻近的神经元.
- 神经元的影响取决于活动调节的相似性;类似调节的神经元被更多地抑制.
- 光刺激导致人群反应减少了约2%,特别是针对目标神经元的首选刺激.
结论:
- V1层2/3执行特征竞争,使用"类似抑制类似"的抑制模式.
- 这种机制减少了人群活动的冗余性,并可能有助于推断感官输入特征.
- 影响映射是一种适用于研究其他神经群体的多功能技术.
相关概念视频
Competition
24.6K
When organisms require the same limited resources within an environment, they may have to compete for them. Competition is a net-negative interaction. Even if two competing individuals or populations do not interact directly, the overall fitness of both competitors is lowered as a result of not having full access to the limited resource.
24.6K
Cell Specific Gene Expression
16.5K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.5K
COPD: Pathogenesis and Clinical Features
1.8K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.8K
Special Features of Adaptive Immunity
3.2K
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
3.2K
Specific Heat
67.4K
The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
67.4K
Esophageal Strictures-II: Clinical Features and Management
600
Patients with esophageal strictures often experience a range of symptoms. Initially, they may have difficulty swallowing solid foods, which can progress to include liquids. Additional symptoms may involve chest pain or discomfort, regurgitating food and fluids, heartburn, unintentional weight loss, coughing or choking during meals, and hoarseness.
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
Healthcare providers should gather a comprehensive medical history and conduct a physical examination for diagnosis. If esophageal stricture is...
600


