相关实验视频
Updated: Jan 28, 2026

08:44
Activating Autophagy by Aerobic Exercise in Mice
Published on: February 3, 2017
12.7K
通过STING贩运诱导自是cGAS通路的原始功能
Xiang Gui1, Hui Yang1, Tuo Li1
1Department of Molecular Biology, Center for Inflammation Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Nature
|March 8, 2019
概括
干扰素基因 (STING) 循环GMP- AMP (cGAMP) 合成酶 (cGAS) 刺激途径激活细胞自,即细胞清洁过程. 这种自诱导对于清除细胞核DNA和病毒至关重要.
科学领域:
- 免疫学
- 细胞生物学
- 分子生物学
背景情况:
- 循环GMP- AMP (cGAMP) 合成酶 (cGAS) 途径检测细胞质DNA,通过STING激活启动免疫反应.
- 通过TBK1激酶激活,通常会导致干扰素的产生.
研究的目的:
- 调查干扰剂诱导之外的STING的作用.
- 阐明STING调节自的机制.
主要方法:
- 调查STING转移到ERGIC和Golgi的情况.
- 评估了LC3脂化和自细胞生物发生.
- 使用基因淘汰和特定途径抑制剂.
- 在海模型中检查了STING功能.
主要成果:
- 独立于TBK1和干扰素信号,STING可以激活自.
- STING转移到ERGIC/Golgi,为自细胞形成提供膜.
- cGAMP诱导的自需要WIPI2和ATG5,但不需要ULK或VPS34复合物.
- 由cGAMP诱导的自有助于清除细胞核DNA和病毒.
结论:
- 在免疫中具有双重作用:干扰素诱导和自激活.
- 通过STING诱导自是一种进化保存的功能,可能是干扰素反应的先驱.
相关概念视频
Autophagy
5.8K
Autophagy is a self-digesting process by which a cell protects itself from threats both within and outside the cell, ranging from abnormal proteins to invading bacteria. In this process, obsolete components of the cell and invading microbes are degraded by hydrolytic enzymes active in an acidic environment of the lysosomal lumen.
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
An autophagic pathway consists of a series of signaling events activated in response to diverse stress and physiological conditions such as food deprivation,...
5.8K
C4 Pathway and CAM
49.1K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
C4 Pathway
The C4 pathway is used by plants such as...
49.1K
Induction
5.7K
An emf is induced when the magnetic field in a coil is changed by pushing a bar magnet into or out of the coil. emfs of opposite signs are produced by motion in opposite directions, and the directions of emfs are also reversed by reversing poles. The same results are produced if the coil is moved rather than the magnet—it is the relative motion that is important. The faster the motion, the greater the emf. Additionally, there is no emf when the magnet is stationary relative to the coil.
A...
A...
5.7K
Other Glycolytic Pathways
885
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
885
Respiration Pathways
773
Cellular respiration is a fundamental metabolic process that enables organisms to generate energy from organic molecules. One of its central pathways is the tricarboxylic acid (TCA) cycle, also known as the Krebs cycle, which plays a crucial role in energy production and biosynthetic processes.Conversion of Pyruvate to Acetyl-CoAThe pyruvate generated from glycolysis undergoes oxidative decarboxylation by the pyruvate dehydrogenase complex, producing acetyl-CoA, one molecule of NADH, and one...
773
Auditory Pathway
7.3K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
7.3K

