使用反氧活性铁复合物的分子磁共振成像
Huan Wang1, Veronica Clavijo Jordan1,2, Ian A Ramsay1
1Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology , Massachusetts General Hospital/Harvard Medical School , 149 Thirteenth Street , Charlestown , Massachusetts 02129 , United States.
Journal of the American Chemical Society
|March 16, 2019
概括
我们开发了一种基于铁的新型MRI对比剂Fe-PyC3A, 通过在体内检测反应性氧物种,使得炎症的精确成像成为可能.
科学领域:
- 生物化学
- 医学成像
- 材料科学
背景情况:
- 目前的MRI对比剂缺乏生化反应.
- 开发用于分子成像的有针对性的对比剂仍然是一个挑战.
研究的目的:
- 引入一种新的氧化还原活性铁复合物Fe-PyC3A,作为一种生化反应敏捷的MRI对比剂.
- 在急性炎症的分子成像中展示它的实用性.
主要方法:
- 合成和表征了氧化还原活性铁复合物Fe-PyC3A.
- 在一系列磁场强度 (1.411.7 T) 中评估的放松性变化.
- 在急性胰腺炎 (caerulein/ LPS) 的小鼠模型中评估了该药物的性能.
主要成果:
- 在Fe3+和Fe2+状态之间,Fe-PyC3A表现出完全大小的场独立放松性变化.
- 通过过氧化观察到Fe2+- PyC3A的快速氧化.
- 在体内实现了炎症胰腺组织的选择性和强烈的对比增强.
- 信号增强与髓氧化酶水平有很强的相关性,这是炎症的生物标志物.
结论:
- 反氧活性Fe3+/2+复合物为设计响应式MRI对比剂提供了一个新的范例.
- Fe-PyC3A可在体内进行由氧化还原活性驱动的病理变化的核磁共振成像.
- 这代表了金属离子氧化还原在体内图像病理学的首次使用.
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