通过在狭窄的人工腔中 U 形折叠,对线性双体进行位置选择性功能化
Hiroki Takezawa1, Tomoya Kanda1, Hikaru Nanjo1
1Department of Applied Chemistry, School of Engineering , The University of Tokyo , 7-3-1 Hongo , Bunkyo-ku, Tokyo 113-8656 , Japan.
Journal of the American Chemical Society
|March 16, 2019
概括
线性双体在协调内经过选择性电友添加. 基板折叠成U形保护内部键,增强反应选择性.
科学领域:
- 超分子化学
- 有机合成
- 催化剂
背景情况:
- 酶利用狭窄的疏水腔预先组织灵活的基质进行选择性反应.
- 在人工系统中实现类似的基质预组织和选择性仍然是一个挑战.
研究的目的:
- 在自组装的协调中展示线性双体的选择性电友添加.
- 研究基质构成在实现增强反应选择性的作用.
主要方法:
- 自动组装一个协调.
- 使用线性二聚作为基质的电友添加反应.
- 在子内对基板的形状分析.
主要成果:
- 协调成功地限制了线性双体,诱导了U形形状.
- 这种U形形态导致了内部碳-碳双键的非共价保护.
- 与未封闭反应相比,在电友添加反应中观察到增强的位点选择性.
结论:
- 自组装的协调可以模仿基质预组织的酶活性位点.
- 在封闭的环境中进行基板折叠是提高有机反应位点选择性的可行策略.
- 这种方法为开发选择性合成方法提供了一个新的平台.
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