通过动态动态分辨率对铜进行催化酸循环添加
En-Chih Liu1, Joseph J Topczewski1
1Department of Chemistry , University of Minnesota Twin Cities , Minneapolis Minnesota 55455 , United States.
Journal of the American Chemical Society
|March 20, 2019
概括
这项研究引入了对铜的选择性催化酸循环添加 (CuAAC) 反应. 这一突破使得能够直接合成具有高产量和反选择性的性三醇.
科学领域:
- 有机化学
- 催化剂
- 化学合成
背景情况:
- 铜 (I) 催化酸循环添加 (CuAAC) 是一种高效的点击反应.
- 由于前体和产品的几何形状以及反应机制的复杂性,在CuAAC中实现对抗选择性是具有挑战性的.
研究的目的:
- 开发一个enantioselectiveCuAAC (E-CuAAC) 的反应.
- 为了能够直接合成alpha-chiral triazoles.
主要方法:
- 使用动态动态分辨率 (DKR) 来实现反选择性.
- 将E-CuAAC反应应用于复杂的分子环境.
主要成果:
- E-CuAAC反应具有很高的产量.
- 达到了高反选择性,反体比 (er) 高达99:1.
- 已经证明可以直接产生阿尔法 - 奇拉三醇.
结论:
- 可行且非常有效的 CuAAC.
- DKR是实现E-CuAAC的一个关键策略.
- 这种方法可以在复杂的环境中合成有价值的性三醇.
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