分子方形和奶奶结的立体选择合成
David A Leigh1, Lucian Pirvu1, Fredrik Schaufelberger1
1School of Chemistry , University of Manchester , Oxford Road , Manchester M13 9PL , U.K.
Journal of the American Chemical Society
|March 21, 2019
概括
研究人员通过立体选择合成了复杂的分子结, 通过使用形上方节点作为构建块来实现这一点,展示了复杂分子结构的新方法.
科学领域:
- 超分子化学
- 有机合成
- 立体化学
背景情况:
- 复杂的分子拓的合成,如结,在化学中是一个重要的挑战.
- 基隆合成子对于构建具有定义立体化学的分子至关重要,类似于基隆方法.
研究的目的:
- 报告一个立体选择合成的分子祖母和方块节点.
- 作为立体化学定义的"纠合成子"利用化物复合的上方结.
主要方法:
- 采用三交叉的高手节点,具有特定的手性作为纠合成.
- 使用铜 (I) 催化酸环添加 (CuAAC) 反应来连接合成子.
- 采用环闭式基转化 (RCM) 来形成闭环结拓.
- 通过NMR光谱学,质谱学和循环二元化进行表征.
主要成果:
- 一个成功的立体选择合成,
- 对于大结节来说,相同的奇拉度和对立的奇拉度的合成声组合的演示.
- 在拓锁定后有效地去除兰他尼德离子.
结论:
- 开发的策略允许从更简单的形构建块构建复杂的结.
- 这种方法为复杂分子结构的立体选择性合成提供了一种新方法.
- 这种方法突出了超分子化学中纠合成子的实用性.
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