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Updated: Jan 27, 2026

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BRCA1的招募限制了MYCN驱动的停滞RNA聚合酶的积累

Steffi Herold1, Jacqueline Kalb2, Gabriele Büchel2

  • 1Theodor Boveri Institute, Department of Biochemistry and Molecular Biology, Biocenter, University of Würzburg, Würzburg, Germany. s.herold@uni-wuerzburg.de.

Nature
|March 22, 2019
PubMed
概括

在神经母细胞瘤中MYCN激活导致RNA聚合酶II (RNAPII) 脱离促进体. 通过MYCN招募BRCA1可以防止RNAPII停滞,并增强转录,帮助瘤存活.

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