使用运动校正切片体积记录的产前MRI对胎儿心脏进行三维可视化:前性单中心队列研究
David F A Lloyd1, Kuberan Pushparajah1, John M Simpson2
1School of Biomedical Engineering & Imaging Sciences, King's College London, King's Health Partners, St Thomas' Hospital, London, UK; Department of Congenital Heart Disease, Evelina London Children's Hospital, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Lancet (London, England)
|March 27, 2019
概括
这项研究表明,将胎儿MRI与运动校正3D软件相结合,可靠地生成胎儿血管的高分辨率3D图像. 这种先进的成像可以比标准的二维心声学更好地诊断先天性心脏病.
科学领域:
- 医学成像
- 心血管科学
- 胎儿医学
背景情况:
- 双维 (2D) 超声心电图是产前诊断先天性心脏病的标准.
- 需要可靠的二次成像,特别是3D血管成像或低质量的超声波.
- 胎儿MRI对胎儿的运动很敏感, 阻碍了3D成像.
研究的目的:
- 为了研究产前MRI与运动校正3D图像记录软件的结合.
- 评估其作为胎儿心声学辅助产生的有用性,以诊断先天性心脏病.
主要方法:
- 85名已知或疑似患有先天性心脏病的胎儿接受了MRI检查.
- 定制的开源软件将二维MRI切片重建成超高分辨率的三维卷.
- 数据集与2D超声波,MRI报告和产后发现进行了比较.
主要成果:
- 在所有85个病例中生成了高分辨率的3D胎儿胸部数据集.
- 与2DMRI相比,3DMRI显著改善了胎儿血管结构的可视化 (97%与53%相比).
- 观察者认为3D数据在90%的病例中具有更高的诊断质量.
结论:
- 标准的胎儿MRI与开源处理可靠地生成高分辨率的胎儿血管成像.
- 3D卷显示与超声波和优异的可视化/诊断质量相比2DMRI.
- 这种免费可用的方法提供了安全,有效和补充的胎儿心血管系统成像.
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