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胚皮与皮膜的连接会影响昆虫的胃化
Stefan Münster1,2,3,4, Akanksha Jain1, Alexander Mietke1,2,3,5
1Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Nature
|March 29, 2019
概括
胚胎组织对保护的粘附产生了影响发育的力量. 这项研究揭示了组织相互作用如何指导昆虫的胃流动,揭示了保存的机制.
科学领域:
- 发育生物学
- 细胞生物学
- 生物物理
背景情况:
- 消化包括物理力量重塑胚胎组织成为复杂的身体计划.
- 已知组织内在收缩驱动胃流动,但周围结构的外部力量较少被理解.
- 胚胎通常被包裹在硬的外中, 引发了关于胚胎在发育机制中的作用的问题.
研究的目的:
- 调查胚胎组织与周围的外之间的相互作用是否会在胃化过程中产生作用.
- 鉴定组织粘的分子机制及其对胚胎发育的影响.
- 确定这种机制是否在不同的昆虫物种中存在.
主要方法:
- 研究了红粉虫 (Tribolium castaneum) 和果 (Drosophila melanogaster) 的胚胎.
- 研究了αPS2整合素 (膨胀) 和αPS3整合素 () 在胚皮粘附中的作用.
- 利用基因敲除来观察胃化表型和分析组织相互作用.
主要成果:
- 发现Tribolium castaneum中的胚皮组织以协调的方式粘附于皮膜.
- 这种粘附会产生反作用力,在胃化过程中会产生不对称的组织运动.
- 对αPS2整合蛋白的破坏破坏了这种连接,导致了胃化缺陷.
结论:
- 组织粘附于皮膜提供了形成胃流动的关键抵制力.
- 这种依赖于特定整合素的机制在Tribolium castaneum和Drosophila melanogaster等昆虫中保持着.
- 组织粘附的时空控制是胚胎形态发生的一个关键因素.
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