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对于食的神经回路的化学感应调节
Sangjun Lee1, Vineet Augustine1, Yuan Zhao1
1Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, USA.
Nature
|March 29, 2019
概括
科学家发现了控制小鼠食欲的特定脑电路. 味觉信号迅速抑制这些循环, 满足食欲并维持平衡.
科学领域:
- 神经科学
- 生理学
- 行为科学
背景情况:
- 对细胞外液体平衡和生理功能至关重要.
- 通过口服检测可以快速满足食欲.
- 基于化学感应的食欲调节的神经机制尚未完全理解.
研究的目的:
- 通过整合味道和内部消耗信号来确定控制摄入的神经回路.
- 调查前表达神经元在食中发挥的作用.
- 阐明食和的神经基础.
主要方法:
- 在小鼠神经回路的遗传识别.
- 在体内光学记录和神经群体的刺激/抑制.
- 逆向病毒追踪以识别上游的神经输入.
- 胃输液以区分口味与摄入效应.
主要成果:
- 在前部表达诺芬的刺激神经元的子集对摄入至关重要.
- 这些神经元的刺激诱导了摄入,而抑制则减少了摄入.
- 通过口服检测迅速抑制这些神经元,导致腹.
- 通过抑制信号进行传感调节的结核中的GABA产生神经元.
结论:
- 已经揭示了集化传感信号和内部平衡需求的神经架构.
- 在前神经元中,prodynorphin神经元作为食的主要基质.
- 味道信号,而不是摄入本身,对于通过抑制神经通路调解的快速和至关重要.
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