通过结构突变和溶液状态组装过程指导拉塞马体的固态组织
Chidambar Kulkarni1, José Augusto Berrocal1, Martin Lutz2
1Laboratory of Macromolecular and Organic Chemistry and Institute for Complex Molecular Systems (ICMS) , Eindhoven University of Technology , P.O. Box 513, 5600 MB Eindhoven , The Netherlands.
Journal of the American Chemical Society
|March 29, 2019
概括
控制分子组合,即使是异构体 (racemates) 的混合物,也是一个挑战. 这项研究表明微妙的结构变化和理解溶液组装可以合理控制转-1,2-非替代循环的固态组织.
科学领域:
- 超分子化学
- 有机化学
- 材料科学
背景情况:
- 对生物分子识别和药物活性至关重要.
- 控制清洁系统的组装是先进的,但赛马仍然具有挑战性.
- 对分子组织的理性控制是先进材料性质的关键.
研究的目的:
- 为了证明对固态组合的理性控制.
- 调查溶液阶段组装和固态组织之间的关系.
- 探索具有不同功能组的转-1,2-非替代循环的组装行为.
主要方法:
- 研究了与碳胺,胺和组合功能组的转基因-1,2- 替代环素.
- 在稀释溶液和缩凝中比较单个反体和赛马体的凝倾向.
- 分析了组装模式,包括自我排序,联合组装和混合组织.
主要成果:
- 碳胺,胺和它们的组合呈现出不同的组装模式:分别是自我分类,联合组装和混合组织.
- 这些溶液相组装行为在固态中成功保留.
- 微妙的分子结构变化影响了组装途径.
结论:
- 溶液相组合研究为理解和控制固态分子组织提供了关键的链接,即使对于种族同伴.
- 超分子结构的理性控制可以通过理解反体和赛马体组合来实现.
- 这项工作提供了一条从分子混合物中可预测的组织的固态材料设计的途径.
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