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Updated: Aug 16, 2026

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma
15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

在Ly 1+ B细胞淋巴瘤中,表达的免疫球蛋白重链基因和生殖系变异基因段之间的重组

R Kleinfield, R R Hardy, D Tarlinton

    Nature
    |August 3, 1986
    PubMed
    概括

    B细胞分化涉及免疫球蛋白基因重组. 在NFS-5淋巴瘤中,可变重量 (VH) 基因之间的新型重组事件取代了基因序列,可能通过嵌入式七度体信号来塑造抗体谱.

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