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在执行和学习运动任务时,共享皮质-小脑动力学
Mark J Wagner1, Tony Hyun Kim2, Jonathan Kadmon3
1Department of Biology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, Stanford, CA 94305, USA.
Cell
|April 2, 2019
概括
在第5层金字塔 (L5) 到小脑颗粒细胞 (GrC) 途径中的神经动力学在运动学习过程中变得相似. 这种皮质-小脑沟通传播共享的神经活动模式,这些模式随着性能的提高而出现.
科学领域:
- 神经科学是一个神经科学.
- 系统神经科学 系统神经科学
- 发动机控制器的控制器
背景情况:
- 哺乳动物新皮质,特别是5层金字塔 (L5) 细胞,通过pones向小脑颗粒细胞 (GrCs) 投射,形成一个关键的神经通路.
- 通过这个L5→GrC路径的神经元动态的转换仍然在很大程度上未被探索.
研究的目的:
- 研究神经元动力学是如何通过L5→GrC路径在运动学习过程中转化.
- 为了比较前肢运动任务期间L5细胞和GrC的神经活动模式.
主要方法:
- 采用双位点两光子成像技术,在前肢运动任务中直接比较小鼠的前运动L5和GrC活动.
- 慢性成像被用来观察神经动态在学习过程中的出现.
主要成果:
- 在专家小鼠中,L5和GrC的神经动态表现出惊人的相似性,共享任务编码模式和响应多样性.
- 观察到L5和GrC活动之间的高度相关性,与L5细胞内的局部相关性相当.
- 在学习过程中,最初不相似的L5和GrC动态汇聚到一个共享的,低维的任务编码模式,随着行为表现的提高.
结论:
- 皮层-小脑沟通的一个关键功能是传播共享的神经动态,在运动学习期间出现.
- L5→GrC通路促进皮质和小脑活动的融合,支持精细的运动控制.
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