死后几个小时恢复大脑循环和细胞功能
Zvonimir Vrselja1,2, Stefano G Daniele1,2,3, John Silbereis1,2
1Department of Neuroscience, Yale School of Medicine, New Haven, CT, USA.
Nature
|April 19, 2019
概括
研究人员使用一种新的输液系统在死后几个小时恢复了猪的大脑功能. 这一突破表明大脑
科学领域:
- 神经科学
- 生理学
- 生物医学工程
背景情况:
- 哺乳动物的大脑很容易受到血液流动和缺氧的影响.
- 在死后保持大脑功能是一个很大的挑战.
研究的目的:
- 恢复和维持哺乳动物大脑中的微循环和细胞功能.
- 为了研究大脑在死后恢复的能力.
主要方法:
- 开发一种体外脉动输液系统.
- 使用一种基于血红蛋白的专用无细胞透剂.
- 在死后4小时内保持正常热量.
主要成果:
- 成功恢复了微循环和分子/细胞功能.
- 观察到细胞结构的保存和细胞死亡的减弱.
- 已证明可以恢复突触活动和大脑代谢.
结论:
- 隔离的哺乳动物大脑在死后有很大的功能恢复能力.
- 开发的系统有效地支持大脑的能量需求,并防止受伤.
- 这项研究为了解和治疗大脑疾病开辟了新的途径.
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