大的神经发育和类头部的演变
Hugo Dutel1,2, Manon Galland3, Paul Tafforeau4
1School of Engineering and Computer Science, Medical and Biological Engineering Research Group, University of Hull, Hull, UK. h.dutel@bristol.ac.uk.
Nature
|April 19, 2019
概括
这项研究揭示了神经如何发育, 这为鱼类进化提供了洞察力.
科学领域:
- 古生物学
- 发育生物学
- 比较解剖学
背景情况:
- 鱼类神经显著进化,具有内关节,后来在肺鱼和早期四足动物中融合.
- 导致神经变化的发育机制尚不清楚.
- (Latimeria) 是唯一保留内关节的活脊椎动物,使其神经发育对进化研究至关重要.
研究的目的:
- 为了研究神经和大脑在Latimeria chalumnae的本体发生.
- 从已知的最早阶段到主要的本体遗传变化描述神经发育.
- 阐明神经发育与相关软组织之间的相互作用.
主要方法:
- 使用常规和同步X射线微计算机断层扫描.
- 使用磁共振成像对一个广泛的增长系列的Latimeria.
- 检查了神经和大脑的发展跨越各种本体遗传阶段.
主要成果:
- 描述了拉蒂梅里亚最早已知的发育阶段的神经.
- 在本体发生过程中记录了神经几何学的显著变化.
- 观察到极端的大脑尺寸缩小和心弦扩大,心弦影响部件,并可能形成内关节.
结论:
- 在形成神经的过程中,脑内带起着重要作用,可能是拉蒂梅里亚人内关节形成的基础.
- 了解Latimeria的神经发育,可以了解sarcopterygian鱼类的神经多样性的演变.
- 这项研究突显了脊椎动物进化过程中软组织和骨发育之间的关键相互作用.
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