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Updated: Jan 26, 2026

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在体内使用DISCOVER-Seq无偏见地检测CRISPR外标

Beeke Wienert1,2,3, Stacia K Wyman1, Christopher D Richardson1,2

  • 1Innovative Genomics Institute, University of California Berkeley, Berkeley, CA 94704, USA.

Science (New York, N.Y.)
|April 20, 2019
PubMed
概括

我们开发了DISCOVER-Seq, 这是一种直接在体内发现CRISPR-Cas基因组编辑异常效应的新方法. 这种方法追踪DNA修复因子MRE11,以精确,单基分解细胞和生物中的Cas活性.

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