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从出生到成年期的体重和肥胖的多基因预测
Amit V Khera1, Mark Chaffin2, Kaitlin H Wade3
1Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Division of Cardiology, Massachusetts General Hospital, Boston, MA 02114, USA; Cardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
Cell
|April 20, 2019
概括
遗传倾向显著影响肥胖风险. 一个使用210万个DNA变异的新多基因预测器量化了遗传易感性,从出生到成年期间显示出大量体重和严重肥胖风险梯度.
科学领域:
- 遗传学
- 公共卫生
- 人类生理学
背景情况:
- 严重肥胖是一个日益严重的全球性健康问题.
- 肥胖是一种遗传性和多基因性疾病,受众DNA变异的影响.
- 目前的理解往往过度强调生活方式和环境因素, 低估了基因的贡献.
研究的目的:
- 开发和验证一种新的多基因预测因子,用于量化遗传的肥胖易感性.
- 评估多基因预测因子与不同年龄组的体重/肥胖风险之间的关系.
- 探索从出生到青春期的遗传影响肥胖的发展轨迹.
主要方法:
- 结合210万种常见遗传变异的多基因预测因子的衍生和验证.
- 在一个超过30万个人的群体中测试预测因素,
- 分析重量和严重肥胖风险梯度的多基因分数.
主要成果:
- 根据多基因分数分数,中年成年人体重 (13公斤) 和严重肥胖风险 (25倍) 显著下降.
- 在纵向出生队列中,发现出生体重差异很小,但在幼儿期出现明显的体重梯度 (12公斤).
- 多基因预测器有效量化了整个生命周期的遗传易感性.
结论:
- 遗传遗传因素在肥胖的发展中起着重要作用,
- 开发的多基因预测器为评估对肥胖的遗传倾向提供了强大的工具.
- 这种方法为个性化临床预防策略和更深入的肥胖机制研究开辟了道路.
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