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Updated: Jan 26, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
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In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila

Published on: August 20, 2019

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人类功能获取MC4R变种显示信号偏差并保护人免于肥胖

Luca A Lotta1, Jacek Mokrosiński2, Edson Mendes de Oliveira2

  • 1University of Cambridge MRC Epidemiology Unit, Wellcome Trust-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.

Cell
|April 20, 2019
PubMed
概括

黑色皮质素4受体 (MC4R) 变异通过影响β- 停滞信号影响肥胖. 功能增强的MC4R变体提供了对肥胖和相关疾病的保护,这表明其具有治疗潜力.

关键词:
GPCRs 的使用情况MC4R 其他英国生物银行有偏差的信号遗传学黑色皮质素肥胖问题维生素B的使用

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