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人类MT1氨酸受体的配体识别的结构基础

Benjamin Stauch1,2, Linda C Johansson1,2, John D McCorvy3,4

  • 1Bridge Institute,USC Michelson Center for Convergent Biosciences, University of Southern California, Los Angeles, CA, USA.

Nature
|April 26, 2019
PubMed
概括

我们确定了与失眠药物和激励剂结合的黑激素受体1 (MT1) 的结构. 这些发现揭示了独特的配体进入机制和芳香相互作用,有助于未来的药物设计,用于昼夜节律障碍.

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