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Jun Nagai¹, Abha K Rajbhandari², Mohitkumar R Gangwani¹

¹Department of Physiology, University of California, Los Angeles, Los Angeles, CA 90095-1751, USA.

|April 30, 2019

概括

状细胞通过涉及GABA_B受体和Thrombospondin-1 (TSP1) 的新型突触通路来控制过度活动和注意力缺陷. 这一发现凸显了星细胞作为相关精神疾病的潜在治疗点.

科学领域:

神经科学
细胞生物学
精神病学

背景情况:

过度活动和注意力缺陷是常见的行为障碍, 细胞和神经回路来源不明.
天体细胞曾经被认为是被动的支持细胞,现在越来越多地被认为是它们在突触功能和神经电路调节中的积极作用.

研究的目的:

阐明细胞和突触机制, 通过这些机制, 天体细胞会导致行为障碍, 如过度活动和注意力缺陷.
在精神疾病中确定神经细胞与神经元通信途径的新疗法目标.

主要方法:

使用化学遗传学在体内选择性激活特定的神经元-星细胞信号通路.
研究了GABA_B受体在条状中脊神经元 (MSN) 和星球细胞之间调解通信中的作用.
分析了突触结构,功能和神经元活动的变化.
检查了对观察到的行为和电路变化的突触性暗示血栓蛋白-1 (TSP1) 阻断的影响.

主要成果:

通过GABA_B受体激活条状星细胞引发了急性行为过活和注意力缺陷.
这种激活导致星球细胞中血栓蛋白-1 (TSP1) 的上调,激发性突触的增加,以及皮质状突触传递的增强.
在体内观察到MSN动作潜力的增加,所有诱导的变化在阻断TSP1时都是可逆的.

结论:

通过GABA_B受体介导的条状神经元和星球细胞之间发现了一种新的双向通信途径.
证明了星细胞突触信号TSP1的急性重新激活可以改变条状电路和行为.
星球细胞和TSP1通路代表过度活动,注意力缺陷和相关精神障碍的有希望的治疗点.

关键词:

天体细胞注意力缺陷行为没有甲素的使用情况过度活动微电路条形状的血小板蛋白

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