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Updated: Jan 25, 2026

Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction
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Author Spotlight: Magnetic Fluorescent Bead-Based Dual-Reporter Flow Analysis of PDL1-Vaxx Peptide Vaccine-Induced Antibody Blockade of the PD-1/PD-L1 Interaction

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在双重CTLA-4和PD-1免疫疗法中,预防性TNF阻断将疗效与毒性脱离

Elisabeth Perez-Ruiz1,2,3,4,5, Luna Minute1,2, Itziar Otano1,2

  • 1Program of Immunology and Immunotherapy, Cima Universidad de Navarra, Pamplona, Spain.

Nature
|May 3, 2019
PubMed
概括

使用PD-1和CTLA-4阻断剂的联合免疫疗法对癌症治疗具有前景,但会引起严重的副作用. 与这些疗法同时使用TNF抑制剂可以降低毒性,同时保持或改善抗瘤功效.

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