乳头神经元的产前活动控制了小鼠的功能性皮质图的出现
Noelia Antón-Bolaños1, Alejandro Sempere-Ferràndez1, Teresa Guillamón-Vivancos1
1Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-Consejo Superior de Investigaciones Científicas (UMH-CSIC), Sant Joan d'Alacant, Spain.
概括
胚胎的乳头活动,而不是感官输入,驱动小鼠体感图的发展. 泰拉木斯中的自发波对于形成功能性脑电路和皮质结构至关重要.
科学领域:
- 神经科学
- 发展神经科学
- 感官系统
背景情况:
- 哺乳动物的体感皮质形成了身体的地形图.
- 在小鼠中,皮质桶代表了胡须输入,但它们的发育起源仍有争议.
- 内在活动与感官输入在地图形成中的作用尚不清楚.
研究的目的:
- 调查皮质结构是否需要感官输入来进行发育,
- 确定胚胎乳头活动在体感图的形成中的作用.
主要方法:
- 在胚胎小鼠中研究了脑皮层柱的发育.
- 监测胚胎体的波活动.
- 观察到皮层电路的发展和体感图组织.
主要成果:
- 在传感输入之前,在小鼠胚胎中出现了脑皮层柱和体内图组织.
- 自发的乳头波先于这些结构的发展并与之相关.
- 甲状腺波的破坏导致皮质电路过度刺激,缺少柱状/桶状组织,以及体感图的混乱.
结论:
- 由自发活动驱动的胚胎 thalamus 中的自我组织的原始地图决定了小鼠 thalamocortical 感官电路的形成.
- 在体感系统的解剖和功能组合中,内在的乳头活动是必不可少的.
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