具有可调节的氧化应激的自组装响应双层囊泡,用于增强癌症成像和治疗
Jibin Song1, Lisen Lin2, Zhen Yang2
1MOE Key Laboratory for Analytical Science of Food Safety and Biology, College of Chemistry , Fuzhou University , Fuzhou 350116 , China.
Journal of the American Chemical Society
|May 5, 2019
概括
我们从Janus纳米颗粒中开发出磁性等离子体囊泡, 这些囊泡释放药物,并在瘤中产生活性氧物种 (ROS),提高治疗效率.
科学领域:
- 纳米技术
- 生物医学工程
- 材料科学
背景情况:
- 化疗的有效性通常受到药物耐药性和副作用的限制.
- 需要有针对性的药物输送系统来改善癌症治疗结果.
- 反应性氧物种 (ROS) 的产生可以增强癌细胞的死亡.
研究的目的:
- 开发用于ROS增强化疗的新型磁性-血双层囊泡.
- 研究这些囊泡的自我组装,特性和治疗潜力.
- 在瘤环境中评估ROS生成和化疗的联合效果.
主要方法:
- 铁氧化物金纳米颗粒 (Fe3O4-Au JNP) 组装成双层囊泡.
- 用聚乙烯糖醇 (PEG) 和产生ROS的聚脂氧化物 (PLHP) 进行表面功能化.
- 自组装的数值模拟,光学和磁性性能的实验验证,pH响应的拆卸,以及使用PET成像的体内研究.
主要成果:
- 由于磁性和等离子合,囊泡表现出增强的T2放松性和光声学特性.
- 在酸性瘤环境中响应pH的分解引发了局部ROS生成.
- 结合ROS介导的细胞毒性和多克索鲁比辛 (DOX) 化学疗法显著改善了治疗效果.
- 通过PET成像证实了高瘤积累和快速清除.
结论:
- 磁性-血双层囊泡为增强化疗提供了一个有前途的平台.
- 这种响应pH,产生ROS的系统有效准和治疗瘤.
- 这种方法代表了纳米医学在癌症治疗中的重大进步.
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