通过糖杯调节膜形状的物理原理
Carolyn R Shurer1, Joe Chin-Hun Kuo1, LaDeidra Monét Roberts2
1Robert Frederick Smith School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, NY 14853, USA.
Cell
|May 7, 2019
概括
由素和多糖化合物组成的细胞表面糖,积极调节细胞膜的形状. 这种相互作用通过热力和膜不稳定性影响细胞通信和细胞外相互作用.
科学领域:
- 细胞生物学
- 生物物理
- 聚合物科学
背景情况:
- 细胞因环境相互作用而动态改变等离子体膜的形状.
- 调节细胞膜曲率的机制尚未完全理解.
研究的目的:
- 研究细胞内过程和细胞表面糖囊在调节血形态中的协同作用.
- 阐明葡萄糖杯的组成和组织如何影响细胞的形状和功能.
主要方法:
- 使用聚合物刷模型模拟葡萄糖杯的行为.
- 分析了聚合物大小和细胞表面密度对膜结构的影响.
- 研究了特定的葡萄糖成分对膜不稳定性和细胞外囊分泌的影响.
主要成果:
- 通过粘素生物聚合物和多糖体,糖囊产生影响细胞表面延伸的力.
- 一个聚合物刷模型准确地预测了聚合物特征如何影响膜形态.
- 特定的葡萄糖成分诱导了膜不稳定性,导致独特的结构和细胞外囊释放.
结论:
- 细胞表面的葡萄糖在调节曲的膜特征中起着至关重要的作用.
- 细胞间和细胞外基质沟通中,糖介导的膜造型至关重要.
- 这项研究揭示了糖控制细胞表面动态的基本机制.
相关概念视频
Physical Principles Governing Gas Exchange
3.5K
Gas behavior plays a vital role in understanding bodily processes such as external and internal respiration. External respiration involves the diffusion of oxygen into the blood and carbon dioxide out of it in the lungs. In contrast, internal respiration happens in body tissues, where these gases move in opposite directions.
Gas Laws Governing Respiration
The behavior of gases is guided by Dalton's Law of partial pressures and Henry's Law.
Dalton's Law asserts that the total...
Gas Laws Governing Respiration
The behavior of gases is guided by Dalton's Law of partial pressures and Henry's Law.
Dalton's Law asserts that the total...
3.5K
Glycocalyx and its Functions
8.2K
The glycocalyx is a carbohydrate-rich, fuzzy-appearing layer on the outer surface of the cell membrane. It is highly hydrophilic, because of this it attracts large amounts of water to the cell's surface. This aids the cell's interaction with the watery environment and also helps it to obtain substances dissolved in the water. It is also important for cell identification, self/non-self determination, and embryonic development and is used in cell-to-cell attachments to form tissues.
8.2K
The Uncertainty Principle
31.4K
Werner Heisenberg considered the limits of how accurately one can measure properties of an electron or other microscopic particles. He determined that there is a fundamental limit to how accurately one can measure both a particle’s position and its momentum simultaneously. The more accurate the measurement of the momentum of a particle is known, the less accurate the position at that time is known and vice versa. This is what is now called the Heisenberg uncertainty principle. He...
31.4K
Membrane Asymmetry Regulating Transporters
7.0K
Enzymes like flippase, floppase, and scramblase transfer phospholipids from one layer to another in the membrane, thereby affecting membrane asymmetry.
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
Flippase
Eukaryotic flippases are type-IV P-type ATPases or P4-ATPases belonging to P-type ATPase family proteins that are membrane-bound pumps involved in the ATP-mediated transport of ions and molecules across the membrane. Flippases flip specific phospholipids from the outer to the inner leaflet of a membrane. All P4-ATPases have one...
7.0K
Hardy-Weinberg Principle
76.1K
Diploid organisms have two alleles of each gene, one from each parent, in their somatic cells. Therefore, each individual contributes two alleles to the gene pool of the population. The gene pool of a population is the sum of every allele of all genes within that population and has some degree of variation. Genetic variation is typically expressed as a relative frequency, which is the percentage of the total population that has a given allele, genotype or phenotype.
76.1K
The Pauli Exclusion Principle
59.1K
The arrangement of electrons in the orbitals of an atom is called its electron configuration. We describe an electron configuration with a symbol that contains three pieces of information:
59.1K


