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Updated: Jan 25, 2026

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伊波梅素F与Sec61α结合以抑制蛋白转位

Guanghui Zong1, Zhijian Hu, Sarah O'Keefe2

  • 1Department of Chemistry and Biochemistry , University of Maryland , College Park , Maryland 20742 , United States.

Journal of the American Chemical Society
|May 7, 2019
PubMed
概括

植物性细胞毒素ipomoeassin F直接与Sec61α (蛋白质运输蛋白Sec61亚单元α异型1) 结合,从而抑制蛋白质转位和分泌. 这一发现为针对Sec61α的癌症药物发现开辟了新的途径.

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