在便免疫化学测试前单次阿司匹林剂量对检测先进结肠直肠瘤的测试灵敏度的影响:随机临床试验
Hermann Brenner1,2,3, Silvia Calderazzo4, Thomas Seufferlein5
1Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
JAMA
|May 8, 2019
概括
单剂量阿司匹林并没有显著改善检测晚期结肠直肠瘤的便免疫化学测试的敏感性. 这项研究不支持使用阿司匹林来提高结直肠癌查测试的准确性.
科学领域:
- 胃肠病学
- 癌症学
- 临床试验
背景情况:
- 便免疫化学测试 (FIT) 对于结直肠癌 (CRC) 查至关重要.
- 之前的研究表明阿司匹林可能会增强FIT对晚期瘤的敏感性,特别是在男性中.
研究的目的:
- 评估一次300mg口服阿司匹林剂量,在便取样前两天,是否可以提高FIT检测晚期结肠直肠瘤的灵敏度.
主要方法:
- 一个随机的,安慰剂控制的,双盲试验,涉及2422名年龄在40至80岁之间的参与者,计划进行结肠镜检查.
- 在FIT采集前两天,参与者接受了300毫克阿司匹林或安慰剂.
主要成果:
- 对于晚期瘤的FIT敏感度为阿司匹林的40. 2%,与安慰剂的30. 4% (p=0. 14) 在一个切断值,和28. 6%与22. 5% (p=0. 32).
- 随着阿司匹林的使用,没有观察到测试灵敏度的统计显著增加.
结论:
- 在FIT之前,单次口服阿司匹林并没有显著提高检测该试验的灵敏度,以检测该人群的晚期结直肠瘤.
- 这些发现不支持使用单次阿司匹林剂量来提高FIT在CRC查中的性能.
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