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在GPCR中高亲和激素结合的分子基础

Tony Warne1, Patricia C Edwards1, Andrew S Doré2

  • 1Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

Science (New York, N.Y.)
|May 11, 2019
PubMed
概括

在活性状态下,G蛋白结合受体 (GPCR) 具有较高的激动因子亲和力. 结构分析显示结合点较小,原子接触增加,解释了这种增强的亲和力.

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