在癌症治疗的离散双阶段金属循环中以光控制生成单片氧气
Yi Qin1, Li-Jun Chen1, Fangyuan Dong1
1Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering , East China Normal University , Shanghai 200062 , PR China.
Journal of the American Chemical Society
|May 16, 2019
概括
研究人员开发了一种新型的金属循环,可用于光动力学治疗,可控制,可逆生成单片氧 (1O2). 这种可以通过纳米粒子切换的"关闭"系统, 通过光激活有效地准并消除癌细胞.
科学领域:
- 超分子化学
- 材料科学
- 纳米技术
背景情况:
- 对单片氧 (1O2) 生产的非侵入性控制对于光动力学治疗至关重要.
- 现有的方法往往缺乏对1O2生产的精确时空控制.
研究的目的:
- 开发一个双阶段的金属循环,用于1O2发电的"关闭"开关.
- 创建一个基于纳米粒子的致癌疗法系统.
主要方法:
- 使用光敏感剂和光色开关构建块合成了双阶段金属循环.
- 用于细胞输送的金属循环载荷纳米粒子.
- 在体外和体内研究了1O2生成和癌细胞毒性.
主要成果:
- 通过分子内能量转移,金属循环表现出可逆的1O2生成"关闭"开关.
- 金属循环纳米粒子向癌细胞提供了有效的传递.
- 与闭环对应物相比,光激活的环开放纳米颗粒的癌细胞毒性显著提高.
- 通过光控制的1O2生成实现了有效的体内瘤消除.
结论:
- 具有双阶段状态的超分子协调复合体为受控的1O2生成提供了多功能纳米平台.
- 开发的系统对非侵入性瘤治疗具有显著的前景.
- 这种方法可以为先进的测量应用提供精确的1O2调节.
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