细胞竞争的不同模式塑造了哺乳动物组织形态
Stephanie J Ellis1, Nicholas C Gomez1, John Levorse1
1Howard Hughes Medical Institute, Robin Neustein Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, New York, NY, USA.
Nature
|May 17, 2019
概括
细胞竞争通过消除不太适合的细胞来优化组织发育. 在小鼠皮肤中,随着组织的分层,这一过程从吞转变为驱逐,确保适当的屏障形成.
科学领域:
- 发育生物学
- 细胞生物学
- 进化生物学
背景情况:
- 细胞竞争,即"输家"细胞被"赢家"细胞淘汰,首次被观察到在Drosophila中.
- 它的进化概论和脊椎动物发展中的作用尚未完全理解.
研究的目的:
- 研究小鼠皮肤发育过程中的细胞竞争机制.
- 确定细胞竞争是否优化脊椎动物的组织结构和功能.
主要方法:
- 现场成像
- 血统追踪
- 单细胞转录组学
- 遗传学
主要成果:
- 在小鼠皮肤发育过程中发现了两个序列性的细胞竞争机制.
- 早期的表皮:获胜的祖先吞了失败的细胞.
- 层化表皮:基底层通过分化后代驱逐输家.
- 这种开关的干扰会破坏皮肤屏障的形成.
结论:
- 细胞竞争是一种优化脊椎动物组织功能的选择力.
- 组织在形态发生过程中动态调整细胞竞争策略以保持健康.
相关概念视频
Competition
24.4K
When organisms require the same limited resources within an environment, they may have to compete for them. Competition is a net-negative interaction. Even if two competing individuals or populations do not interact directly, the overall fitness of both competitors is lowered as a result of not having full access to the limited resource.
24.4K
Morphogenesis
30.4K
Plant morphogenesis—the development of a plant’s form and structure—involves several overlapping developmental processes, including growth and cell differentiation. Precursor cells differentiate into specific cell types, which are organized into the tissues and organ systems that make up the functional plant.
30.4K
What is a Mode?
25.1K
The mode is one of the commonly used measures of a central tendency. It is defined as the most frequent value in a data set.
There can be more than one mode in a data set if multiple values have the same highest frequency. For instance, suppose that the Statistics exam scores of 20 students are: 50; 53; 59; 59; 63; 63; 72; 72; 72; 72; 72; 76; 78; 81; 83; 84; 84; 84; 90; 93. Here, the mode is 72, as it occurs most frequently, five times.
A data set with two modes is called bimodal. For example,...
There can be more than one mode in a data set if multiple values have the same highest frequency. For instance, suppose that the Statistics exam scores of 20 students are: 50; 53; 59; 59; 63; 63; 72; 72; 72; 72; 72; 76; 78; 81; 83; 84; 84; 84; 90; 93. Here, the mode is 72, as it occurs most frequently, five times.
A data set with two modes is called bimodal. For example,...
25.1K
Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
4.5K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
4.5K
Molecular Shape and Polarity
74.9K
Dipole Moment of a Molecule
74.9K
VSEPR Theory and the Basic Shapes
84.2K
Overview of VSEPR Theory
84.2K


