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来自中枢神经系统的原始细胞在癌症中驱动神经发生

Philippe Mauffrey¹, Nicolas Tchitchek², Vilma Barroca¹

¹UMR967 (Laboratoire Cancer et Microenvironnement ATIP/AVENIR-INSERM-CEA), Institut de Radiobiologie Cellulaire et Moléculaire, Institut de Biologie François Jacob, Direction de la Recherche Fondamentale, Paris, France.

|May 17, 2019

概括

来自中枢神经系统的表达双皮质素 (DCX+) 的神经原体透到前列腺瘤中,启动神经发生并促进癌症生长. 它们的消耗抑制了瘤的发展, 揭示了中枢神经系统瘤交叉声和潜在的神经治疗点.

科学领域:

神经科学
癌症学
癌症生物学

背景情况:

自主神经影响癌症, 但它们在瘤中的起源尚不清楚.
神经前代在瘤神经发生中的作用在很大程度上是未知的.
了解瘤中的神经突出对于癌症治疗至关重要.

研究的目的:

在前列腺癌中研究神经元的起源和作用.
确定中枢神经系统的神经原始体是否透到瘤中.
探索针对前列腺癌神经通路的治疗潜力.

主要方法:

使用前列腺癌的小鼠模型.
在中枢神经系统和瘤中表达双皮质素 (DCX+) 的追踪神经基因.
评估DCX+细胞枯竭和移植对瘤发育的影响.
与DCX+原始体密度相关的人类前列腺癌的攻击性.

主要成果:

来自中枢神经系统的双皮质素阳性 (DCX+) 神经基因透到前列腺瘤和转移.
这些原始体在瘤微环境中启动神经发生.
从中枢神经系统的DCX+细胞退出与血脑屏障的破坏有关.
在小鼠中,DCX+细胞的消耗抑制了前列腺癌的进展.
移植DCX+基因增强了瘤的生长和转移.
人类前列腺癌的侵袭性和复发性与DCX+原始细胞密度相关.

结论:

来自中枢神经系统的神经原始体有助于前列腺瘤的启动,生长和转移.
在中枢神经系统和前列腺瘤之间存在一种新的交叉通话.
在前列腺癌治疗中,DCX+神经基因是潜在的治疗点.

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