在新生小鼠行为中的下丘脑Agrp神经元的功能本体化
Marcelo R Zimmer1, Antonio H O Fonseca2, Onur Iyilikci3
1Program in Integrative Cell Signaling and Neurobiology of Metabolism, Department of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA; Graduate Program in Biological Sciences-Biochemistry, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS 90035, Brazil.
Cell
|May 21, 2019
概括
在小鼠吃饭之前,下丘脑的阿古蒂相关 (Agrp) 神经元在隔离时激活,而不是饥饿. 这表明这些神经元可能支持早期后代与照顾者的联系.
科学领域:
- 神经科学
- 发育生物学
- 行为生物学
背景情况:
- 已知Agrp神经元是成年小鼠食物摄入的调节者.
- 这些神经元在独立养开始前的功能状况在很大程度上仍未被探索.
研究的目的:
- 研究小鼠在出生后早期的下丘脑Agrp神经元的功能性发育.
- 确定激活新生小鼠Agrp神经元的刺激.
主要方法:
- 在生后第10天的小鼠中使用纤维光度测量来监测Agrp神经元活动.
- 化学遗传学被用来操纵Agrp神经元的活动.
- 实验包括从哺乳巢控制的隔离, 剥夺牛奶, 非营养哺乳, 和温度变化.
主要成果:
- 在新生小鼠中,与哺乳巢隔离,而不是剥夺或摄入,强烈激活了Agrp神经元.
- 不营养的哺乳和温暖的环境温度通过隔离减弱了Agrp神经元的激活.
- 在隔离时Agrp神经元活动迅速增加,在与 littermates重聚时减少.
- 从Agrp神经元释放GABA受损的新生儿显示隔离诱导的超声波发声减少.
- Agrp神经元的化学过度激活增加了超声波发声,但没有影响牛奶摄入.
结论:
- 在新生小鼠中,下丘脑Agrp神经元在断奶前是功能活跃的,并且对社会隔离有反应.
- 这些神经元似乎在与分离相关的痛苦发声中起作用.
- 这些发现表明Agrp神经元在促进早期后代与照顾者的结合方面发挥了潜在的作用,超出了它们在调节养方面的已知作用.
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