概括
实验性链球菌内心炎的短期抗生素预防在高细菌注射量的情况下失败了. 最佳持续时间因细菌物种而异,单独的阿莫西西林对病毒性链球菌有效,但对Enterococcus faecalis.需要组合治疗.
科学领域:
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
- 微生物学 微生物学
背景情况:
- 对实验性链球菌内心炎的抗生素预防有不一致的成功,特别是在高细菌注射量的情况下.
- 在这些条件下,抗生素的最佳持续时间用于预防内心炎仍未确定.
研究的目的:
- 为了确定抗生素的必要持续时间,以预防由高耐受性viridans-group streptococci和Streptococcus faecalis的高注射剂引起的实验性内心炎.
- 为了比较单独的阿莫西西林与阿莫西西林与 gentamicin 结合的疗效,用于预防.
主要方法:
- 使用了一种具有导管诱导无菌大动脉植被的老鼠模型.
- 接种了大剂量 (100-10,000倍90%的传染剂量) 的两种维里丹菌群链球菌和两种Streptococcus faecalis菌株的小鼠.
- 多次服用单独的阿莫西西林或阿莫西西林加上 gentamicin 剂量,持续时间不同.
主要成果:
- 单独服用多剂量阿莫西西林,在24-48小时内服用时,可以预防病毒性链球菌内心炎.
- 当阿莫西西林加上 جنت米辛在6-24小时内给药时,可以预防病毒性链球菌内心炎.
- 单独的阿莫西西林在S. faecalis预防中失败了;只有在48-72小时内服用时,组合治疗才成功.
结论:
- 单独重复服用β-乳糖抗生素就足以预防高剂量挑战后的病毒性链球菌内心炎.
- 在类似的条件下,多剂量杀菌组合 (β-乳酸加氨基糖化物) 对于成功预防S. faecalis内心炎至关重要.
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