青春期较高的体重指数预测了中年心肌病的风险
Josefina Robertson1,2, Maria Schaufelberger3,2, Martin Lindgren3,2
1Department of Public Health and Community Medicine/Primary Health Care (J.R., M.A.), Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden.
Circulation
|May 29, 2019
概括
轻微的青少年肥胖会显著增加成人心肌病的风险,尤其是扩张型. 年轻人控制体重对于预防不良心脏重塑和心力衰竭至关重要.
科学领域:
- 心脏病学
- 公共卫生
- 流行病学
背景情况:
- 心肌病是年轻人心力衰竭的原因之一.
- 影响心肌病风险的可改变的生活方式因素,特别是在年轻人中,需要进一步调查.
- 青少年肥胖是早期心力衰竭的预测因素.
研究的目的:
- 研究青少年肥胖与成人心肌病发病风险之间的关联.
- 探索青少年体质指数 (BMI) 与特定类型心肌病之间的联系.
主要方法:
- 一项全国性的基于登记的前性队列研究,涉及1,668,893名青少年男性.
- 基线数据包括BMI,血压,健身和肌肉力量.
- 在46年的随访期间,通过国家登记处追踪心肌病诊断,并使用Cox比例危险模型进行分析.
主要成果:
- 在青春期增加的BMI和心肌病风险增加之间发现了强烈的关联,特别是扩张性心肌病.
- 即使是正常范围的BMI (22.524.9 kg/ m2) 也与1. 38倍的风险增加有关.
- 与18. 519. 9kg/ m2的BMI相比,BMI≥35kg/ m2的风险增加了8倍以上.
结论:
- 青少年体重增加,即使是轻微的,也与成人心肌病的风险增加有关.
- 这些发现强调了年轻人控制体重对心血管健康的重要性.
- 肥胖可能是不良心脏重塑的重要独立因素,不论是缺血性心脏病.
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