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BRISC-SHMT2组件的代谢控制调节免疫信号

Miriam Walden1, Lei Tian2, Rebecca L Ross3

  • 1Astbury Centre for Structural Molecular Biology, School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, UK.

Nature
|May 31, 2019
PubMed
概括

代谢物调节炎症信号. 这项研究揭示了不活跃的Serine hydroxymethyltransferase 2 (SHMT2) 双重酶如何抑制BRCC36异酶复合体 (BRISC),影响细胞因子反应和I型干扰素信号传递.

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