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在VTA多巴胺神经元中对感觉,运动和认知变量的专门编码
Ben Engelhard1,2, Joel Finkelstein1,3, Julia Cox1
1Princeton Neuroscience Institute, Princeton University, Princeton, NJ, USA.
Nature
|May 31, 2019
概括
中脑中的多巴胺神经元表现出专门的角色,不同的亚群编码特定的行为变量. 这种功能和空间组织有助于下游电路解释复杂的多巴胺信号.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
背景情况:
- 已知中脑中的多巴胺神经元对奖励和奖励线索做出反应.
- 新出现的证据表明,这些神经元还编码其他变量,如距离到奖励,运动和行为选择.
- 了解这些多样化的信号是如何在多巴胺神经元群体中组织的,是一个关键的未解决的问题.
研究的目的:
- 研究多巴胺神经元编码的各种变量的组织.
- 为了确定单个多巴胺神经元是否复杂信息,或者是否存在专门的子群.
主要方法:
- 利用双光子成像来记录小鼠腹膜区域300多个多巴胺神经元的活动.
- 采用复杂的虚拟现实决策任务,同时评估对多个变量的反应.
主要成果:
- 发现多巴胺神经元在导航和决策过程中编码了广泛的感觉,运动和认知变量.
- 响应在功能上是集群的,这表明子群体专门编码特定的行为变量与奖励一起.
- 这些功能集群表现出空间组织,邻近的神经元表现出类似的响应特性.
结论:
- 多巴胺神经元群体在功能上是专门的,在空间上是有组织的,子群体编码了不同的行为变量集.
- 这种组织,加上投影拓,可能有助于下游神经回路解释复杂的多巴胺信号.
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