在糖尿病前期的宿主微生物动态的纵向多组学
Wenyu Zhou1, M Reza Sailani1, Kévin Contrepois1
1Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA.
Nature
|May 31, 2019
概括
了解早期2型糖尿病 (T2D) 揭示了不同的个人健康状况和独特的宿主微生物相互作用. 早期的分子特征,包括炎症标志物,可能会在T2D发病之前出现.
科学领域:
- 代谢健康
- 免疫学
- 微生物组研究
背景情况:
- 第二类糖尿病 (T2D) 对健康构成越来越大的挑战,
- 研究从健康状态过渡到糖尿病前期和T2D对于早期干预策略至关重要.
研究的目的:
- 阐明与T2D进展有关的最早的分子和微生物变化.
- 在健康和糖尿病前状态下描述个体变异性.
- 在葡萄糖失调中识别宿主微生物相互作用和免疫反应.
主要方法:
- 在4年内从106名健康和糖尿病前患者中进行纵向采样.
- 深度多基因分析:转录组,代谢组,蛋白组和细胞因子分析.
- 微生物组测序和宿主微生物相互作用的分析.
主要成果:
- 健康个体表现出明显的个人特征,具有显著的内部和人际变异性.
- 呼吸道病毒感染和免疫引发广泛的宿主和微生物变化,具有明显的免疫反应.
- 与胰岛素敏感个体相比,胰岛素耐药个体对病毒感染的反应不同.
- 特定的宿主微生物相互作用在胰岛素抵抗和胰岛素敏感状态之间存在差异.
- 在一个人身上发现了T2D发病前的早期分子特征,包括IL-1RA和CRP.
结论:
- 这项研究为分离健康,糖尿病前和T2D状态的分子和微生物途径提供了新的见解.
- 已识别的宿主微生物相互作用和免疫反应为T2D研究提供了潜在的目标.
- 这一全面的开放式数据集将有助于进一步调查T2D病原和早期检测.
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