3组先天性淋巴细胞介导早期的抗结核免疫力
Amanda Ardain1,2, Racquel Domingo-Gonzalez3, Shibali Das3
1Africa Health Research Institute, Durban, South Africa.
Nature
|June 7, 2019
概括
结核病患者的先天性淋巴细胞 (ILC) 已经耗尽,但在肺部积累,帮助免疫反应. 3组ILCs (ILC3) 对于控制Mycobacterium结核病 (Mtb) 感染至关重要.
科学领域:
- 免疫学
- 传染性疾病
- 细胞生物学
背景情况:
- 结核病 (TB) 仍然是全球主要的传染病死亡原因.
- 在Mycobacterium tuberculosis (Mtb) 感染免疫力中,先天性淋巴细胞 (ILCs) 的作用尚不清楚.
研究的目的:
- 调查ILCs在对Mtb感染的免疫反应中的参与.
- 阐明ILC子集,特别是ILC3s在结核病发病和控制中的特定功能.
主要方法:
- 对结核病患者和健康对照者的血液和肺组织中的ILC子集的分析.
- 使用了Mtb感染的小鼠模型,包括ILC3缺乏的小鼠.
- 在ILC功能中研究了CXCR5-CXCL13轴和细胞因子信号传递 (IL-23,IL-17,IL-22).
主要成果:
- 结核病患者的循环ILCs减少,而肺部ILCs则累积.
- ILC3s在感染Mtb的小鼠肺部迅速积累,促进大膜巨细胞的招募.
- 缺少ILC3的小鼠表现出对Mtb的控制受损,并降低了早期的先天免疫力.
- 鉴定出CXCR5- CXCL13通路和IL-23信号传递对ILC3介导的免疫反应和颗粒瘤形成至关重要.
结论:
- ILC3s在早期对MTB感染的免疫力中起着保护作用.
- ILC3s调节先天性免疫反应,包括巨细胞的招募和细粒体内淋巴卵泡的形成.
- 针对ILC3s和相关途径可能为结核病提供新的治疗策略.
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