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相关概念视频

Group Design02:01

Group Design

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The most basic experimental design involves two groups: the experimental group and the control group. The two groups are designed to be the same except for one difference— experimental manipulation. The experimental group gets the experimental manipulation—that is, the treatment or variable being tested—and the control group does not. Since experimental manipulation is the only difference between the experimental and control groups, we can be sure that any differences between...
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Factorial Design02:01

Factorial Design

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Factorial Analysis is an experimental design that applies Analysis of Variance (ANOVA) statistical procedures to examine a change in a dependent variable due to more than one independent variable, also known as factors. Changes in worker productivity can be reasoned, for example, to be influenced by salary and other conditions, such as skill level. One way to test this hypothesis is by categorizing salary into three levels (low, moderate, and high) and skills sets into two levels (entry level...
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Design Example: Designing a Residential Plumbing System01:25

Design Example: Designing a Residential Plumbing System

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The design of residential plumbing systems requires carefully evaluating water demand, flow rates, and pressure dynamics to ensure both efficiency and reliability. The nature of water flow within pipes is defined by its Reynolds number, which classifies flow as either laminar (smooth) or turbulent.
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Design Example: Designing Water Slide01:18

Design Example: Designing Water Slide

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When designing a water slide, controlling the speed of water flow is crucial for rider safety while maintaining an exciting experience. As water flows down the slide, gravity causes it to accelerate, with its speed at the bottom depending on the height from which it starts. The higher the slide, the more potential energy the water has at the top, which is converted into kinetic energy as it descends, increasing its speed.
Bernoulli's principle determines the water's velocity along the slide....
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Design Example: Design of an Irrigation Channel01:27

Design Example: Design of an Irrigation Channel

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Trapezoidal channels are widely used in irrigation systems due to their cost-effectiveness and efficiency in conveying water. Trapezoidal channels feature a flat bottom and sloping sides, making them stable and easier to construct compared to other shapes. The bottom width and side slope ratio are determined based on the required flow capacity and site conditions. The side slope is kept gentle for unlined channels to prevent soil erosion.Hydraulic parameters in channel design include the flow...
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Design Example01:23

Design Example

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The innovation of touch-tone telephony revolutionized the telecommunications industry by replacing the traditional rotary dial with a dual-tone multi-frequency (DTMF) signaling system. This system uses a matrix-style keypad with buttons arranged in four rows and three columns, creating 12 distinct signals each assigned to a pair of frequencies. Each button press results in a simultaneous generation of two sinusoidal tones – one from a low-frequency group (697 to 941 Hz) and one from a...
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相关实验视频

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Organoid-Derived Epithelial Monolayer: A Clinically Relevant In Vitro Model for Intestinal Barrier Function
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Organoid-Derived Epithelial Monolayer: A Clinically Relevant In Vitro Model for Intestinal Barrier Function

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设计中的器官

Takanori Takebe1,2,3,4, James M Wells1,3,5

  • 1Center for Stem Cell and Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. james.wells@cchmc.org takanori.takebe@cchmc.org.

Science (New York, N.Y.)
|June 8, 2019
PubMed
概括
此摘要是机器生成的。

有机体工程旨在通过控制细胞组装和发育来创建复杂的功能组织. 未来的器官设计将利用工程原理来精确控制组织模式,生长和功能.

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科学领域:

  • 生物技术和再生医学
  • 发育生物学
  • 组织工程

背景情况:

  • 器官是自组织的3D培养,模仿器官结构和功能,来自干细胞或成年组织.
  • 目前的有机体模型具有不同的复杂性,从简单的结构到具有多种细胞类型的无组织组织.
  • 一个关键的挑战是为有组织的组装和功能性组织发展而控制细胞的复杂性.

研究的目的:

  • 讨论工程先进的有机体与受控的细胞复杂性和组织功能.
  • 探索发育生物学见解如何为下一代器官设计提供信息.
  • 提出基于工程的叙事设计方法,以精确控制器官的发展.

主要方法:

  • 利用胚胎器官组合的研究来指导器官发育.
  • 应用工程原理来控制关键的发育过程:模式,组装,形态,生长和功能.
  • 设计具有多层组织复杂性和更高阶功能的器官.

主要成果:

  • 具有多层组织复杂性的有机体的发展.
  • 在工程器官中获得更高阶的功能.
  • 展示受控的组装和组织组织的发展.

结论:

  • 下一代器官可以使用基于工程的叙述方法来设计.
  • 这种方法可以精确控制器官的模式,组装,形态发生,生长和功能.
  • 未来的有机体工程对先进的再生医学和疾病建模具有前途.