食品安全的社会传播取决于前额叶皮层的突触可塑性
Michaël Loureiro1, Ridouane Achargui1, Jérôme Flakowski1
1Department of Basic Neurosciences, Medical Faculty, University of Geneva, CH-1211 Geneva, Switzerland.
概括
通过嗅觉从他人那里学到食物安全性. 食物偏好的社会传播涉及中枢前额皮层 (mPFC) 的突触可塑性,将嗅觉感知与行动联系起来.
科学领域:
- 神经科学
- 嗅觉处理
- 社会学习
背景情况:
- 动物使用嗅觉线索和社会信号来决定食物摄入.
- 皮质皮质 (PiC) 处理嗅觉信息,而核 (NAc) 参与消费.
- 转化嗅觉感知到基于价值的行为的神经基础尚未完全理解.
研究的目的:
- 研究食品安全社会传播的神经回路和细胞机制.
- 通过同类来学习食品安全的脑部区域和突触过程.
主要方法:
- 在小鼠之间食物信息的社交传输过程中监测中部前额皮层 (mPFC) 中的神经元活动.
- 在NAc投射神经元中测量刺激后突触电流.
- 阻止从PiC到mPFC的神经传输以评估其作用.
主要成果:
- 在食物信息社会传输后,mPFC神经元投射到NAc中观察到神经元活动的增强.
- 在NAc投射器中暴露于同种类的强化刺激后突触电流.
- 抑制从PiC传播到mPFC消除了食品安全的社会传播.
结论:
- 在mPFC中的突触可塑性作为食品安全的社会传播的细胞基质.
- 从PiC到mPFC到NAc的神经通路对于这个过程至关重要.
- 这项研究阐明了社会嗅觉如何影响食物的接受.
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