Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

siRNA - Small Interfering RNAs02:30

siRNA - Small Interfering RNAs

18.5K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.5K
piRNA - Piwi-interacting RNAs02:57

piRNA - Piwi-interacting RNAs

7.6K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.6K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

9.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

3.6K
3.6K
Small interfering RNAs (siRNA)02:30

Small interfering RNAs (siRNA)

4.3K
4.3K
What is Behavior?00:54

What is Behavior?

10.2K
Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
10.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Neuronal RNAi and oxygen-sensing circuit shape germline resilience to heat stress.

Current biology : CB·2026
Same author

Differential Radiomodulatory Effects of Sodium Aminodihydrophthalazinedione (Tameron<sup>®</sup>) on Normal and Cancer Cells Cultures: Antioxidant Activity, DNA Damage Response, and Transcriptomic Profiling.

International journal of molecular sciences·2026
Same author

An epifluorescence microscope design for naturalistic behavior and cellular activity in freely moving Caenorhabditis elegans.

Nature communications·2026
Same author

Reframing healthcare workplace violence: Compassion without complacency.

Journal of hospital medicine·2026
Same author

Scavenger Cells Failure to Maintain Systemic RNA Homeostasis Causes Epigenetically Inherited Germline Tumors.

bioRxiv : the preprint server for biology·2026
Same author

Perspectives on increasing corporate ownership and unionization in hospital medicine: An exploratory mixed methods study.

Journal of hospital medicine·2026
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
查看所有相关文章

相关实验视频

Updated: Jan 23, 2026

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

11.5K

神经小RNAs控制行为跨代

Rachel Posner1, Itai Antoine Toker1, Olga Antonova1

  • 1Department of Neurobiology, Wise Faculty of Life Sciences and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv 6997801, Israel.

Cell
|June 11, 2019
PubMed
概括
此摘要是机器生成的。

在C. elegans线虫中,神经元活动可以跨代传承. 神经元产生调节基因表达和控制后代行为的小RNA,证明了跨代神经元的交流.

关键词:
类植物表观遗传神经小RNA非孟德尔遗传小RNA遗传跨代遗传

更多相关视频

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

3.8K
A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo
13:44

A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

Published on: September 2, 2013

19.5K

相关实验视频

Last Updated: Jan 23, 2026

Control of Eating Behavior Using a Novel Feedback System
04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

11.5K
In Vivo Wireless Optogenetic Control of Skilled Motor Behavior
07:52

In Vivo Wireless Optogenetic Control of Skilled Motor Behavior

Published on: November 22, 2021

3.8K
A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo
13:44

A Method for High Fidelity Optogenetic Control of Individual Pyramidal Neurons In vivo

Published on: September 2, 2013

19.5K

科学领域:

  • 神经科学
  • 遗传学
  • 分子生物学

背景情况:

  • 神经系统活动的遗传性尚不清楚.
  • 小RNA可以调节Caenorhabditis elegans的跨代基因调节.

研究的目的:

  • 研究神经元活动是否可以跨代传承.
  • 阐明小RNA在神经元功能的跨代遗传中的作用.

主要方法:

  • 研究了C. elegans神经元中的小RNA合成.
  • 分析了神经小RNA对生殖基因表达和后代行为的影响.
  • 这些小RNA的确定的目标,包括saeg-2基因.

主要成果:

  • 神经元合成RDE-4依赖的小RNA,可以调节多代的生殖基因表达.
  • 通过HRDE-1,神经小RNA至少控制后代的化学反应行为.
  • 赛格-2基因的跨代下调是由神经小RNA介导的,对于压力诱导的化学反应至关重要.

结论:

  • 神经元活动可以通过小RNA传递给后代.
  • 一种基于小RNA的新机制促进了神经元过程的跨代沟通.
  • 这种机制影响后代的基因表达和行为,强调神经元功能与遗传性特征之间的联系.