鼻癌
Yu-Pei Chen1, Anthony T C Chan2, Quynh-Thu Le3
1Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, People's Republic of China.
Lancet (London, England)
|June 11, 2019
概括
鼻癌的发病率和死亡率正在下降,原因是了解情况的改善,用血埃普斯坦-巴尔病毒 (EBV) DNA进行查,以及强度调节放射治疗和免疫治疗等先进的治疗方法.
科学领域:
- 癌症学
- 流行病学
- 病毒学
背景情况:
- 鼻癌 (NPC) 的地理分布不同,特别是在东亚和东南亚.
- 最近的流行病学趋势表明NPC发病率逐渐下降,死亡率大幅降低.
- 这些变化归因于不断变化的生活方式,环境因素以及对NPC病变的更好理解.
研究的目的:
- 审查鼻癌治疗的最新进展.
- 要突出血爱斯坦-巴尔病毒 (EBV) DNA 在查和监测中的作用.
- 讨论现代放射疗法和化疗对患者结果的影响.
主要方法:
- 鼻癌的流行病学趋势和临床结果的综述.
- 用于查和预后的Epstein-Barr病毒 (EBV) DNA的应用分析.
- 评估强度调节的放射治疗和最佳化疗策略.
- 评估包括免疫检查点抑制剂在内的新疗法.
主要成果:
- 在过去十年中,鼻癌发病率和死亡率显著降低.
- 血爱斯坦-巴尔病毒 (EBV) DNA 在人口查,预后和监测方面被证明是有效的.
- 强度调节放射治疗和优化化疗方案改善了生存率并降低了毒性.
- 免疫检查点治疗对复发性或转移性鼻癌具有前景.
结论:
- 了解,查和治疗方面的进步使鼻癌的结果有所改善.
- 血爱斯坦-巴尔病毒 (EBV) DNA 在鼻癌的多学科治疗中是一个有价值的工具.
- 新的治疗方法, 特别是免疫检查点抑制剂, 为晚期鼻癌提供了充满希望的未来.
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