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检查艾滋病毒感染:美国预防服务工作组建议声明
, Douglas K Owens1,2, Karina W Davidson3
1Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
JAMA
|June 12, 2019
概括
建议所有15至65岁的青少年和成年人,包括孕妇,进行人类免疫缺陷病毒 (HIV) 感染查. 早期检测和治疗在减少与艾滋病毒相关的并发症和传播方面具有显著的好处.
科学领域:
- 公共卫生
- 传染性疾病
- 预防医学
背景情况:
- 在美国,艾滋病毒仍然是一个重大的公共卫生问题,
- 尽管由于查和干预措施,艾滋病毒在产后传播率有所下降,但这是一个关键问题.
- 美国预防服务工作组 (USPSTF) 在2013年发布了建议.
研究的目的:
- 更新2013年USPSTF对青少年,成年人和孕妇的艾滋病毒查建议.
- 评估艾滋病毒查和治疗策略的益处和危害.
主要方法:
- 对艾滋病毒查的证据进行系统审查,包括测试准确性,查间隔和治疗开始值.
- 对非孕妇和孕妇的抗逆转录病毒治疗 (ART) 的益处和危害的评估.
- 关于预防母婴艾滋病毒传播和怀孕期间ART安全性的证据的审查.
主要成果:
- 目前的艾滋病毒检测非常准确.
- 艾滋病毒的早期发现和治疗显著降低了艾滋病相关事件和死亡率.
- 抗逆转录病毒治疗 (ART) 大大降低了对性伴侣的艾滋病毒传播和母婴传播.
- 有关ART的一些危害,包括神经,和肝脏的影响,以及早产风险增加.
结论:
- 美国公共卫生卫生检查委员会建议15至65岁的青少年和成年人以及风险较高的年轻人/老年人进行艾滋病毒查.
- 所有孕妇都应该接受艾滋病毒查, 即使在分娩时出现在未知状态的人.
- 艾滋病毒查对这些人群的净好处是显著的.
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