预防艾滋病毒感染的暴露前预防:美国预防服务工作组建议声明
, Douglas K Owens1,2, Karina W Davidson3
1Veterans Affairs Palo Alto Health Care System, Palo Alto, California.
JAMA
|June 12, 2019
概括
在高危人群中,预暴露预防 (PrEP) 显著降低了艾滋病毒风险. 坚持是PREP的关键
科学领域:
- 公共卫生
- 传染性疾病
- 预防医学
背景情况:
- 美国有超过110万人感染艾滋病毒,2017年新诊断人数为38,281人.
- 尽管艾滋病毒感染是可以治疗的,
- 美国预防服务工作组 (USPSTF) 发布有关预防卫生服务的建议.
研究的目的:
- 更新USPSTF关于预防艾滋病毒暴露前预防 (PrEP) 的建议.
- 评估PrEP治疗方案的有效性和安全性,以减少艾滋病毒感染风险.
主要方法:
- 对PrEP的益处,风险和坚持的证据进行系统审查.
- 分析风险评估工具的诊断准确性,以识别高风险人群.
- 评估与初级保健中的坚持率有关的PrEP有效性.
主要成果:
- 有令人信服的证据表明PrEP对艾滋病毒感染风险较高的人有很大益处.
- 准备剂的有效性与坚持密切相关;坚持是实现益处的关键.
- 准备与轻微的危害相关,如脏和胃肠道不良影响.
结论:
- USPSTF建议提供有效的抗逆转录病毒疗法给高危人群.
- 在降低艾滋病毒感染风险方面,PrEP的实质性益处得到了很高的确定性.
- 坚持PrEP是预防艾滋病毒感染的关键.
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