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  2. 在2型糖尿病中杜拉古和结局:rewind随机对照试验的探索性分析
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  2. 在2型糖尿病中杜拉古和结局:rewind随机对照试验的探索性分析

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在2型糖尿病中杜拉古和结局:REWIND随机对照试验的探索性分析

Hertzel C Gerstein1, Helen M Colhoun2, Gilles R Dagenais3

  • 1Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, ON, Canada.

Lancet (London, England)
|June 14, 2019

在PubMed 上查看摘要

概括
此摘要是机器生成的。

在2型糖尿病患者中,杜拉古是一种类似葡萄糖类-1受体激动剂,显著降低了复合结局. 这一发现突显了其对脏健康的潜在益处.

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科学领域:

  • 肝脏病学
  • 内分泌学
  • 临床试验

背景情况:

  • 葡萄糖类-1 (GLP-1) 受体激动剂在降低心血管风险的2型糖尿病患者的结局方面具有显著的益处.
  • 之前的REWIND试验评估了GLP-1受体激动剂杜拉格卢提德的心血管作用.

研究的目的:

  • 探讨杜拉格卢提德对2型糖尿病患者结局的长期影响
  • 分析杜拉格卢提德对新出现的大albuminuria,持续的eGFR下降和替代疗法的影响.

主要方法:

  • 一个多中心,随机,双盲,安慰剂对照试验 (REWIND) 涉及9901名2型糖尿病患者.
  • 参与者每周接受杜拉格卢提德 (1. 5毫克) 或安慰剂,并对结局进行随访,包括新增的大albuminuria,eGFR下降和替代疗法.
  • 治疗意向分析是在5. 4年的中位随访期内进行的.

主要成果:

  • 与安慰剂相比,dulaglutide使复合结结果降低了15% (HR为0. 85,p=0. 0004).
  • 观察到新发生的大albuminuria的显著减少 (HR 0. 77, p< 0. 0001).
  • 趋势表明持续的EGFR下降 (HR 0. 89, p=0. 066) 和置换治疗 (HR 0. 75, p=0. 39) 有益.

结论:

  • 在2型糖尿病患者中,长期使用杜拉格卢与综合性结局的降低有关.
  • 杜拉古具有显著的保护作用,可以防止新的宏蛋白尿症的发生.