移徙记忆B细胞在阴道内分泌光抗体
Ji Eun Oh1, Norifumi Iijima1,2,3, Eric Song1
1Department of Immunobiology, Yale School of Medicine, New Haven, CT, USA.
Nature
|June 14, 2019
概括
在女性生殖系统中,循环记忆B细胞在二次感染时迅速分泌抗体. 这种机制绕过了当地的血细胞,为粘膜免疫提供了一条新的途径来对抗像单纯疹病毒2这样的病原体.
科学领域:
- 免疫学
- 粘膜免疫力
- 生殖健康
背景情况:
- 粘膜屏障对病原体进行保护,在肠道 (I型粘膜) 中进行二次IgA介导保护.
- 由于局部血细胞和聚合物免疫球蛋白受体有限,对女性下生殖道 (II型粘膜) 的抗体传递知之甚少.
研究的目的:
- 调查抗体输送到女性生殖道光线的机制.
- 确定保护女性下生殖道免受感染的抗体来源.
主要方法:
- 在小鼠的生殖器疹感染模型.
- 分析女性生殖管中的血细胞,B细胞和T细胞反应.
- 化学激素和受体参与的研究 (CXCL9,CXCL10,CXCR3).
主要成果:
- 主要的生殖器疹感染没有在女性生殖道内形成血细胞.
- 在第二次刺激时,循环的B细胞进入了肠道并分泌了抗体.
- CD4组织内存T细胞产生干扰素-γ,诱导通过CXCR3招募记忆B细胞的化学因子.
- 病毒特异性IgG2b,IgG2c和IgA被招募的记忆B细胞分泌到光膜中.
结论:
- 循环记忆B细胞是女性生殖道光体中抗体的重要来源.
- 这种机制在女性下生殖道中提供了快速,可诱导的粘膜免疫力.
- 在该部位发现一种新的抗体介导保护途径,与I型粘膜不同.
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