表面的糖会给细胞提供形状
1Department of Chemistry and Biochemistry, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0358, USA.
Cell
|June 15, 2019
概括
细胞外层的葡萄糖杯可以控制细胞膜的形状和曲率. 这一发现揭示了从细胞外表调节细胞形态的新机制.
科学领域:
- 细胞生物学
- 生物物理
- 葡萄糖生物学
背景情况:
- 细胞膜表现出不同的形状和曲率,对于细胞功能至关重要.
- 控制细胞形状的精确机制尚未完全理解.
- 细胞表面的复杂碳水化合物层,具有细胞识别和保护的作用,但其对细胞形状的影响较少被探索.
研究的目的:
- 研究葡萄糖在调节细胞膜形状和曲率中的作用.
- 阐明外部因素,特别是糖如何影响细胞内结构和细胞形态.
主要方法:
- 使用先进的显微镜技术可视化细胞膜动态.
- 使用生物化学测定来分析葡萄糖的组成和完整性.
- 开发了计算模型来模拟细胞膜上糖所施加的物理力.
主要成果:
- 证明葡萄糖能积极影响和限制细胞膜的曲率.
- 表明葡萄糖结构的改变与细胞形状的变化直接相关.
- 确定了负责调解这些形状调节效应的特定葡萄糖成分.
结论:
- 葡萄糖杯作为细胞外形的关键调节器,从细胞外表起作用.
- 这种外部调节机制为细胞机制和形态发生提供了新的见解.
- 这些发现为了解与细胞形态变化相关的疾病打开了道路.
相关概念视频
Phloem and Sugar Transport
39.8K
Like many living organisms, plants have tissues that specialize in specific plant functions. For example, shoots are well adapted to rapid growth, while roots are structured to acquire resources efficiently. However, sugar production is primarily restricted to the photosynthetic cells that reside in the leaves of angiosperm plants. Sugar and other resources are transported from photosynthetic tissues to other specialized tissues by a process called translocation.
39.8K
Molecular Shape and Polarity
74.7K
Dipole Moment of a Molecule
74.7K
Cell-surface Signaling
54.0K
Hormones—or any molecule that binds to a receptor, known as a ligand—that are lipid-insoluble (water-soluble) are not able to diffuse across the cell membrane. In order to be able to affect a cell without entering it, these hormones bind to receptors on the cell membrane. When a first messenger, a hormone, binds to a receptor, a signal cascade is set off, causing second messengers, proteins inside the cell, to become activated, resulting in downstream effects.
54.0K
Sugars as Energy Storage Molecules
9.8K
Sugar (a simple carbohydrate) metabolism (chemical reactions) is a classic example of the many cellular processes that use and produce energy. Living things consume sugar as a major energy source because sugar molecules have considerable energy stored within their bonds. Consumed carbohydrates have their origins in photosynthesizing organisms like plants. During photosynthesis, plants use the energy of sunlight to convert carbon dioxide gas into sugar molecules, like glucose. Because this...
9.8K
VSEPR Theory and the Basic Shapes
84.2K
Overview of VSEPR Theory
84.2K
Molecular Shapes
61.5K
Molecules have characteristic shapes that are crucial for their function. The arrangement of various electron groups around the central atom dictates their molecular geometry. Electron pairs in the valence shell of a central atom will adopt an arrangement that minimizes repulsions between the electron pairs by maximizing the distance between them. The valence electrons form either bonding pairs, located primarily between bonded atoms, or lone pairs.
Two regions of electron density in a diatomic...
Two regions of electron density in a diatomic...
61.5K


