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自我报告的产前大麻使用与孕产妇,产周和新生儿结局之间的关联
Daniel J Corsi1,2,3, Laura Walsh4, Deborah Weiss3,4
1Ottawa Hospital Research Institute, Ottawa, Ontario, Canada.
产前大麻使用与早产和其他新生儿不良后果的风险增加有关. 这项研究强调了怀孕期间使用大麻的潜在风险.
科学领域:
- 围产期健康
- 生殖流行病学
- 大麻研究
背景情况:
- 怀孕期间大麻使用率的增加需要有关周产期结局的数据.
- 有限的基于人群的研究存在于子宫内大麻暴露的影响.
研究的目的:
- 调查自我报告的产前大麻使用与孕产妇和周围产生的不良结果之间的关联.
- 在怀孕期间接触大麻后,量化特定不良结果的风险.
主要方法:
- 在加拿大安大略省 (2012-2017) 进行基于人口的回顾性队列研究.
- 包括15岁以上妇女的活产和死产.
- 通过产周护理确定使用大麻的自我报告.
- 使用粗精确匹配和Poisson回归来分析结果.
主要成果:
- 在661,617名妇女中,1.4%报告在怀孕期间使用大麻.
- 报告中的大麻使用与早产风险增加41%有关 (RR, 1.41).
- 与怀孕年龄相比较小 (RR,1. 53),胎盘断裂 (RR,1. 72),新生儿重症监护室转移 (RR,1. 40) 和低Apgar分数 (RR,1.28) 发现的重要关联.
结论:
- 在怀孕期间自我报告的大麻使用与早产风险的增加显著相关.
- 这些发现表明,与产前大麻接触相关的潜在不良周围结果.
- 其余的混可能会限制最终的结论.
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